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Treatment of Eye Herpes (Herpes Simplex Keratitis) For HSV epithelial keratitis, initiate combination therapy with topical ganciclovir 0 15% gel (3-5 times daily) plus oral antiviral therapy (valacyclovir 500 mg 2-3 times daily, acyclovir 400 mg five times daily, or famciclovir 250 mg twice daily)—oral therapy alone is insufficient to control active corneal disease 1

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